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KMID : 0043320010240020119
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Archives of Pharmacal Research
2001 Volume.24 No. 2 p.119 ~ p.125
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Toxicology of Kalopanax pictus Extract and Hematological Effect of the Isolated Anti-Rheumatoidal Kalopanaxsaponin A on the Freunds Complete Adjuvant Reagent-Treated Rat
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Choi JW
Huh K/Kim SH/Lee KT/Kwon SH/Park HJ
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Abstract
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We have reported that kalopanaxsaponin A(KPS-A) isolated from Kalopanax pictus have antirheumatoidal activity in the rat treated with Freunds complete adjuvant(FCA) regent. In a ddition, it has been also reported that KPS-A is a potent antioxidant in the rheumatiodal rat. This research was undertaken to examine whether the saponins of KSP-A and -l could adjust the abnormal lipid metabfolisms and hematological change in immunological diseases. KSP-A significantly inhibited the increases in both trig lycerides and total proteins in addition to the decrease in total cholesterol induced by FCA reagent treament.KPS-A treatment drcreased the number of leucocytes elevater by FCA reagent treatmetn. Excess dose of the methanol extract produced no severe toxicity on the body weight, wet organ weights and hepatic functions. Since LD50 value of K. pictus methanol extract was shown to be 4,033mg/kg, it could be estimaed to be a safe agent for anti-rheumatoidal herbal medicines.
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